全文获取类型
收费全文 | 2595467篇 |
免费 | 221409篇 |
国内免费 | 23570篇 |
学科分类
医药卫生 | 2840446篇 |
出版年
2021年 | 26683篇 |
2019年 | 26076篇 |
2018年 | 33339篇 |
2017年 | 26897篇 |
2016年 | 28199篇 |
2015年 | 34869篇 |
2014年 | 47750篇 |
2013年 | 62679篇 |
2012年 | 86330篇 |
2011年 | 92644篇 |
2010年 | 54882篇 |
2009年 | 50338篇 |
2008年 | 81187篇 |
2007年 | 85513篇 |
2006年 | 86761篇 |
2005年 | 85189篇 |
2004年 | 76944篇 |
2003年 | 74121篇 |
2002年 | 72012篇 |
2001年 | 116888篇 |
2000年 | 121603篇 |
1999年 | 103986篇 |
1998年 | 30481篇 |
1997年 | 28214篇 |
1996年 | 27221篇 |
1995年 | 27849篇 |
1994年 | 25817篇 |
1993年 | 23300篇 |
1992年 | 81170篇 |
1991年 | 77934篇 |
1990年 | 74865篇 |
1989年 | 71931篇 |
1988年 | 66735篇 |
1987年 | 65521篇 |
1986年 | 61888篇 |
1985年 | 58863篇 |
1984年 | 44418篇 |
1983年 | 37702篇 |
1982年 | 22874篇 |
1979年 | 41288篇 |
1978年 | 28910篇 |
1977年 | 24246篇 |
1976年 | 22753篇 |
1975年 | 23902篇 |
1974年 | 29585篇 |
1973年 | 28008篇 |
1972年 | 26204篇 |
1971年 | 24141篇 |
1970年 | 22724篇 |
1969年 | 21062篇 |
排序方式: 共有10000条查询结果,搜索用时 17 毫秒
71.
72.
ObjectiveTo evaluate the efficacy and safety of prompt phacoemulsification, intraocular lens implantation, visco-goniosynechialysis, combined with pseudo-pupilloplasty for refractory acute primary angle closure (APAC) with atonic dilated pupil and to describe a feasible method of pupilloplasty.MethodsA consecutive series of refractory APAC patients who had atonic dilated pupil and undergone prompt phacoemulsification combined with pseudo-pupilloplasty at our center were retrospectively analyzed. Pseudo-pupilloplasty referred to a method of pupilloplasty which included 4.5-mm capsulorhexis, postoperative opacification of anterior capsule residue, and ultimate pseudo-pupil formation. Preoperative and postoperative measurements included intraocular pressure (IOP), best corrected visual acuity (BCVA), and anterior chamber depth (ACD). Intraoperative and postoperative complications were documented. The process of pseudo-pupil formation was also observed.ResultsA total of 20 eyes of 19 APAC patients were followed up for 19.7 ± 9.8 months. IOP was lowered from preoperative 44.0 ± 9.8 mmHg to 15.5 ± 2.6 mmHg at final visit (t = 11.945, P < 0.001). ACD was deepened from preoperative 1.77 ± 0.21 mm to 3.40 ± 0.20 mm at final visit (t = –27.711, P < 0.001). Twelve of 20 eyes had residual angle synechiae, whereas only 3 eyes needed anti-glaucoma medications. No severe complication was observed. All eyes had pseudo-pupil gradually formed within 3 months, accompanied with the gradual improvement of BCVA from preoperative 1.18 ± 0.55 to 0.58 ± 0.22, 0.26 ± 0.09, 0.11 ± 0.09, and 0.11 ± 0.09 at postoperative day 1, month 1, month 3, and last visit.ConclusionsPrompt phacoemulsification-goniosynechialysis is effective and safe for refractory APAC with atonic dilated pupil. Pseudo-pupilloplasty is a feasible procedure for pupil reconstruction. 相似文献
73.
A 2-year-old girl was diagnosed as Weill-Marchesani syndrome with typical systemic features of short stature, short and stubby hands and feet, language disorders and mental retardation. He developed bilateral angle closure glaucoma, ectopia lentis and suffered visual loss from the ocular features of Weill-Marchesani syndrome. The child was successfully treated by combined CO2 laser-assisted sclerectomy surgery and trabeculectomy. 相似文献
74.
75.
76.
Weina Cheng Yazhi Wang Jingxian Liu Xiaofei Li Ming Yu Cancan Duan Liu Liu Jianyong Zhang 《Journal of applied toxicology : JAT》2022,42(6):970-980
Cantharidin (CTD) is an effective antitumor agent. However, it exhibits significant hepatotoxicity, the mechanism of which remains unclear. In this study, biochemical and histopathological analyses complemented with ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS)-based targeted metabolomic analysis of bile acids (BAs) were employed to investigate CTD-induced hepatotoxicity in rats. Sixteen male and female Sprague–Dawley rats were randomly divided into two groups: control and CTD (1.0 mg/kg) groups. Serum and liver samples were collected after 28 days of intervention. Biochemical, histopathological, and BA metabolomic analyses were performed for all samples. Further, the key biomarkers of CTD-induced hepatotoxicity were identified via multivariate and metabolic pathway analyses. In addition, metabolite–gene–enzyme network and Kyoto Encyclopedia of Genes and Genomes pathway analyses were used to identify the signaling pathways related to CTD-induced hepatotoxicity. The results revealed significantly increased levels of biochemical indices (alanine aminotransferase, aspartate aminotransferase, and total bile acid). Histopathological analysis revealed that the hepatocytes were damaged. Further, 20 endogenous BAs were quantitated via UHPLC-MS/MS, and multivariate and metabolic pathway analyses of BAs revealed that hyocholic acid, cholic acid, and chenodeoxycholic acid were the key biomarkers of CTD-induced hepatotoxicity. Meanwhile, primary and secondary BA biosynthesis and taurine and hypotaurine metabolism were found to be associated with the mechanism by which CTD induced hepatotoxicity in rats. This study provides useful insights for research on the mechanism of CTD-induced hepatotoxicity. 相似文献
77.
Guo Chengyao Yin Shengjie Qiu Kunliang Zhang Mingzhi 《International ophthalmology》2022,42(7):2029-2038
International Ophthalmology - To evaluate and compare the accuracy of six different formulas (Emmetropia Verifying Optical version 2.0, Kane, SRK/T, Barrett Universal II, Haigis and Olsen) in... 相似文献
78.
79.
Delirium is one of the most commonly occurring postoperative complications in older adults. It occurs due to the vulnerability of cerebral functioning to pathophysiological stressors. Identification of those at increased risk of developing delirium early in the surgical pathway provides an opportunity for modification of predisposing and precipitating risk factors and effective shared decision-making. No single delirium prediction tool is used widely in surgical settings. Multi-component interventions to prevent delirium involve structured risk factor modification supported by geriatrician input; these are clinically efficacious and cost effective. Barriers to the widespread implementation of such complex interventions exist, resulting in an ‘implementation gap’. There is a lack of evidence for pharmacological prophylaxis for the prevention of delirium. Current evidence suggests that avoidance of peri-operative benzodiazepines, careful titration of anaesthetic depth guided by processed electroencephalogram monitoring and treatment of pain are the most effective strategies to minimise the risk of delirium. Addressing postoperative delirium requires a collaborative, whole pathway approach, beginning with the early identification of those patients who are at risk. The research agenda should continue to examine the potential for pharmacological prophylaxis to prevent delirium while also addressing how successful models of delirium prevention can be translated from one setting to another, underpinned by implementation science methodology. 相似文献